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1

X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice

Montay-Gruel, Pierre, Bouchet, Audrey, Jaccard, Maud, Patin, David, Serduc, Raphael, Aim, Warren, Petersson, Kristoffer, Petit, Benoit, Bailat, Claude, Bourhis, Jean, Bräuer-Krisch, Elke, Vozenin, Mar

Journal:

Radiotherapy and Oncology

Year:

2018

Language:

english

File:

PDF, 1.45 MB

english, 2018

2

Faster and safer? FLASH ultra-high dose rate in radiotherapy

Durante, Marco, Brauer-Krisch, Elke, Hill, Mark

Journal:

British Journal of Radiology

Year:

2017

Language:

english

File:

PDF, 1.28 MB

english, 2017

3

Thin silicon strip detectors for beam monitoring in Micro-beam Radiation Therapy

Povoli, M., Alagoz, E., Bravin, A., Cornelius, I., Bräuer-Krisch, E., Fournier, P., Hansen, T. E., Kok, A., Lerch, M., Monakhov, E., Morse, J., Petasecca, M., Requardt, H., Rosenfeld, A. B., Röhrich,

Journal:

Journal of Instrumentation

Year:

2015

Language:

english

File:

PDF, 4.51 MB

english, 2015

4

DNA double strand breaks in the acute phase after synchrotron pencilbeam irradiation

Fernandez-Palomo, C, Bräuer-Krisch, E, Trippel, M, Schroll, C, Requardt, H, Bartzsch, S, Nikkhah, G, Schültke, E

Journal:

Journal of Instrumentation

Year:

2013

Language:

english

File:

PDF, 1.38 MB

english, 2013

5

X-Tream: a novel dosimetry system for Synchrotron Microbeam Radiation Therapy

Petasecca, M, Cullen, A, Fuduli, I, Espinoza, A, Porumb, C, Stanton, C, Aldosari, A H, Bräuer-Krisch, E, Requardt, H, Bravin, A, Perevertaylo, V, Rosenfeld, A B, Lerch, M L F

Journal:

Journal of Instrumentation

Year:

2012

Language:

english

File:

PDF, 3.68 MB

english, 2012

6

Investigation of Abscopal and Bystander Effects in Immunocompromised Mice After Exposure to Pencilbeam and Microbeam Synchrotron Radiation

Fernandez-Palomo, Cristian, Schültke, Elisabeth, Bräuer-Krisch, Elke, Laissue, Jean Albert, Blattmann, Hans, Seymour, Colin, Mothersill, Carmel

Journal:

Year:

2016

Language:

english

File:

PDF, 433 KB

english, 2016

7

Benchmarking and validation of a Geant4–SHADOW Monte Carlo simulation for dose calculations in microbeam radiation therapy

Cornelius, Iwan, Guatelli, Susanna, Fournier, Pauline, Crosbie, Jeffrey C., Sanchez del Rio, Manuel, Bräuer-Krisch, Elke, Rosenfeld, Anatoly, Lerch, Michael

Journal:

Journal of Synchrotron Radiation

Year:

2014

Language:

english

File:

PDF, 1.19 MB

english, 2014

8

CMR 2007: 3.05: Use of a Gd-chelate as a dose enhancement agent for synchrotron microbeam radiation therapy applied to rodent brain tumors

G. Le Duc, P. Regnard, R. Serduc, S. Roux, E. Bräuer-Krisch, O. Tillement, A. Bravin

Journal:

Contrast Media & Molecular Imaging

Year:

2007

Language:

english

File:

PDF, 46 KB

english, 2007

9

Exploiting geometrical irradiation possibilities in MRT application

E. Bräuer-Krisch, H. Requardt, P. Régnard, S. Corde, E.A. Siegbahn, G. LeDuc, H. Blattmann, J. Laissue, A. Bravin

Journal:

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

Year:

2005

Language:

english

File:

PDF, 158 KB

english, 2005

10

The thermoluminescence response of Ge-doped silica fibres for synchrotron microbeam radiation therapy dosimetry

A.T. Abdul Rahman, D.A. Bradley, S.J. Doran, Brochard Thierry, Elke Bräuer-Krisch, A. Bravin

Journal:

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

Year:

2010

Language:

english

File:

PDF, 174 KB

english, 2010

11

Tolerance of Arteries to Microplanar X-Ray Beams

Boudewijn van der Sanden, Elke Bräuer-Krisch, Erik Albert Siegbahn, Clément Ricard, Jean-Claude Vial, Jean Laissue

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2010

Language:

english

File:

PDF, 2.11 MB

english, 2010

12

Preferential Effect of Synchrotron Microbeam Radiation Therapy on Intracerebral 9L Gliosarcoma Vascular Networks

Audrey Bouchet, Benjamin Lemasson, Géraldine Le Duc, Cécile Maisin, Elke Bräuer-Krisch, Erik Albert Siegbahn, Luc Renaud, Enam Khalil, Chantal Rémy, Cathy Poillot, Alberto Bravin, Jean A. Laissue, Emm

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2010

Language:

english

File:

PDF, 1.97 MB

english, 2010

13

Microbeam Radiation-Induced Tissue Damage Depends on the Stage of Vascular Maturation

Sara Sabatasso, Jean Albert Laissue, Ruslan Hlushchuk, Werner Graber, Alberto Bravin, Elke Bräuer-Krisch, Stéphanie Corde, Hans Blattmann, Guenther Gruber, Valentin Djonov

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2011

Language:

english

File:

PDF, 3.45 MB

english, 2011

14

Synergy of gene-mediated immunoprophylaxis and microbeam radiation therapy for advanced intracerebral rat 9L gliosarcomas

H.M. Smilowitz, H. Blattmann, E. Bräuer-Krisch, A. Bravin, M. Di Michiel, J.-O. Gebbers, A. L. Hanson, N. Lyubimova, D. N. Slatkin, J. Stepanek, J. A. Laissue

Journal:

Journal of Neuro-Oncology

Year:

2006

Language:

english

File:

PDF, 231 KB

english, 2006

15

Applications of synchrotron X-rays to radiotherapy

H. Blattmann, J.-O. Gebbers, E. Bräuer-Krisch, A. Bravin, G. Le Duc, W. Burkard, M. Di Michiel, V. Djonov, D.N. Slatkin, J. Stepanek, J.A. Laissue

Journal:

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

Year:

2005

Language:

english

File:

PDF, 295 KB

english, 2005

16

Dosimetric studies of microbeam radiation therapy (MRT) with Monte Carlo simulations

E.A. Siegbahn, E. Bräuer-Krisch, J. Stepanek, H. Blattmann, J.A. Laissue, A. Bravin

Journal:

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

Year:

2005

Language:

english

File:

PDF, 196 KB

english, 2005

17

Imaging and dosimetry of synchrotron microbeam with aluminum oxide fluorescent detectors

J.A. Bartz, G.J. Sykora, E. Bräuer-Krisch, M.S. Akselrod

Journal:

Radiation Measurements

Year:

2011

Language:

english

File:

PDF, 483 KB

english, 2011

18

Dosimetry of intensive synchrotron microbeams

M.L.F. Lerch, M. Petasecca, A. Cullen, A. Hamad, H. Requardt, E. Bräuer-Krisch, A. Bravin, V.L. Perevertaylo, A.B. Rosenfeld

Journal:

Radiation Measurements

Year:

2011

Language:

english

File:

PDF, 545 KB

english, 2011

19

Memory and survival after microbeam radiation therapy

Elisabeth Schültke, Bernhard H.J. Juurlink, Khalid Ataelmannan, Jean Laissue, Hans Blattmann, Elke Bräuer-Krisch, Alberto Bravin, Joanna Minczewska, Jeffrey Crosbie, Hadi Taherian, Evan Frangou, Tomas

Journal:

European Journal of Radiology

Year:

2008

Language:

english

File:

PDF, 542 KB

english, 2008

20

Enhancement of survival of 9L gliosarcoma bearing rats following intracerebral delivery of drugs in combination with microbeam radiation therapy

Pierrick Régnard, Elke Bräuer-Krisch, Irène Troprès, Jani Keyriläinen, Alberto Bravin, Géraldine Le Duc

Journal:

European Journal of Radiology

Year:

2008

Language:

english

File:

PDF, 158 KB

english, 2008

21

Effects of pulsed, spatially fractionated, microscopic synchrotron X-ray beams on normal and tumoral brain tissue

E. Bräuer-Krisch, R. Serduc, E.A. Siegbahn, G. Le Duc, Y. Prezado, A. Bravin, H. Blattmann, J.A. Laissue

Journal:

Mutation Research/Reviews in Mutation Research

Year:

2010

Language:

english

File:

PDF, 350 KB

english, 2010

22

Sophisticated test objects for the quality assurance of optical computed tomography scanners

Abdul Rahman, A T, Bräuer-Krisch, Elke, Brochard, Thierry, Adamovics, John, Clowes, S K, Bradley, David, Doran, Simon J

Journal:

Physics in Medicine and Biology

Year:

2011

Language:

english

File:

PDF, 2.05 MB

english, 2011

23

New irradiation geometry for microbeam radiation therapy

Bräuer-Krisch, E, Requardt, H, Régnard, P, Corde, S, Siegbahn, E, LeDuc, G, Brochard, T, Blattmann, H, Laissue, J, Bravin, A

Journal:

Physics in Medicine and Biology

Year:

2005

Language:

english

File:

PDF, 701 KB

english, 2005

24

Impact of dose-rate on the low-dose hyper-radiosensitivity and induced radioresistance (HRS/IRR) response*

Thomas, Charles, Martin, Jennifer, Devic, Clément, Bräuer-Krisch, Elke, Diserbo, Michel, Thariat, Juliette, Foray, Nicolas

Journal:

International Journal of Radiation Biology

Year:

2013

Language:

english

File:

PDF, 657 KB

english, 2013

25

Toward an Image-Guided Microbeam Radiation Therapy Using Gadolinium-Based Nanoparticles

Le Duc, Géraldine, Miladi, Imen, Alric, Christophe, Mowat, Pierre, Bräuer-Krisch, Elke, Bouchet, Audrey, Khalil, Enam, Billotey, Claire, Janier, Marc, Lux, François, Epicier, Thierry, Perriat, Pascal,

Journal:

Year:

2011

Language:

english

File:

PDF, 2.99 MB

english, 2011

26

Synchrotron microbeam radiation therapy induces hypoxia in intracerebral gliosarcoma but not in the normal brain

Bouchet, Audrey, Lemasson, Benjamin, Christen, Thomas, Potez, Marine, Rome, Claire, Coquery, Nicolas, Le Clec’h, Céline, Moisan, Anaick, Bräuer-Krisch, Elke, Leduc, Géraldine, Rémy, Chantal, Laissue,

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 1.21 MB

english, 2013

27

Proteomic changes in the rat brain induced by homogenous irradiation and by the bystander effect resulting from high energy synchrotron X-ray microbeams

Smith, Richard W., Wang, Jiaxi, Schültke, Elisabeth, Seymour, Colin B., Bräuer-Krisch, Elke, Laissue, Jean A., Blattmann, Hans, Mothersill, Carmel E.

Journal:

International Journal of Radiation Biology

Year:

2013

Language:

english

File:

PDF, 328 KB

english, 2013

28

Synchrotron microbeam radiation therapy for rat brain tumor palliation—influence of the microbeam width at constant valley dose

Serduc, Raphaël, Bouchet, Audrey, Bräuer-Krisch, Elke, Laissue, Jean A, Spiga, Jenny, Sarun, Sukhéna, Bravin, Alberto, Fonta, Caroline, Renaud, Luc, Boutonnat, Jean, Siegbahn, Erik Albert, Estève, Fra

Journal:

Physics in Medicine and Biology

Year:

2009

Language:

english

File:

PDF, 739 KB

english, 2009

29

The In Vivo Radiosensitizing Effect of Gold Nanoparticles Based MRI Contrast Agents

Miladi, Imen, Alric, Christophe, Dufort, Sandrine, Mowat, Pierre, Dutour, Aurélie, Mandon, Céline, Laurent, Gautier, Bräuer-Krisch, Elke, Herath, Nirmitha, Coll, Jean-Luc, Dutreix, Marie, Lux, Françoi

Journal:

Year:

2014

Language:

english

File:

PDF, 805 KB

english, 2014

30

Determination of ion recombination for absolute dosimetry in microbeam radiation therapy

Fournier, P., Clavel, A.H., Cornelius, I., Berkvens, P., Crosbie, J.C., Lerch, M.L.F., Rosenfeld, A.B., Brauer-Krisch, E.

Journal:

Year:

2013

Language:

english

File:

PDF, 103 KB

english, 2013

31

Response of the rat spinal cord to X-ray microbeams

Laissue, Jean A., Bartzsch, Stefan, Blattmann, Hans, Bräuer-Krisch, Elke, Bravin, Alberto, Dalléry, Dominique, Djonov, Valentin, Hanson, Albert L., Hopewell, John W., Kaser-Hotz, Barbara, Keyriläinen,

Journal:

Radiotherapy and Oncology

Year:

2013

Language:

english

File:

PDF, 1.11 MB

english, 2013

32

Synchrotron X-ray interlaced microbeams suppress paroxysmal oscillations in neuronal networks initiating generalized epilepsy

Pouyatos, Benoît, Serduc, Raphaël, Chipaux, Mathilde, Chabrol, Tanguy, Bräuer-Krisch, Elke, Nemoz, Christian, Mathieu, Hervé, David, Olivier, Renaud, Luc, Prezado, Yolanda, Laissue, Jean Albert, Estèv

Journal:

Neurobiology of Disease

Year:

2013

Language:

english

File:

PDF, 2.51 MB

english, 2013

33

Monte Carlo code comparison of dose delivery prediction for microbeam radiation therapy

Felici, M De, Siegbahn, E A, Spiga, J, Hanson, A L, Felici, R, Ferrero, C, Tartari, A, Gambaccini, M, Keyriläinen, J, Bräuer-Krisch, E, Randaccio, P, Bravin, A

Journal:

Journal of Physics Conference Series

Year:

2008

Language:

english

File:

PDF, 401 KB

english, 2008

34

Establishing the suitability of quantitative optical CT microscopy of PRESAGE® radiochromic dosimeters for the verification of synchrotron microbeam therapy

Doran, Simon J, Abdul Rahman, A T, Bräuer-Krisch, Elke, Brochard, Thierry, Adamovics, John, Nisbet, Andrew, Bradley, David

Journal:

Physics in Medicine and Biology

Year:

2013

Language:

english

File:

PDF, 1.78 MB

english, 2013

35

Medical physics challenges within the Microbeam Radiation Therapy (MRT) project

Bräuer-Krisch, E., Nemoz, C., Brochard, T., Renier, M., Requardt, H., Serduc, R., LeDuc, G., Bravin, A., Bartzsch, S., Fournier, P., Cornelius, I., Berkvens, P., Crosbie, J.C., Lerch, M.L.F., Rosenfel

Journal:

Year:

2014

Language:

english

File:

PDF, 48 KB

english, 2014

36

Microbeam Radiation Therapy Alters Vascular Architecture and Tumor Oxygenation and is Enhanced by a Galectin-1 Targeted Anti-Angiogenic Peptide

Griffin, Robert J, Koonce, Nathan A, Dings, Ruud P. M, Siegel, Eric, Moros, Eduardo G, Bräuer-Krisch, Elke, Corry, Peter M

Journal:

Radiation Research

Year:

2012

Language:

english

File:

PDF, 1.24 MB

english, 2012

37

Characterization and quantification of cerebral edema induced by synchrotron x-ray microbeam radiation therapy

Serduc, Raphaël, van de Looij, Yohan, Francony, Gilles, Verdonck, Olivier, van der Sanden, Boudewijn, Laissue, Jean, Farion, Régine, Bräuer-Krisch, Elke, Siegbahn, Erik Albert, Bravin, Alberto, Prezad

Journal:

Physics in Medicine and Biology

Year:

2008

Language:

english

File:

PDF, 274 KB

english, 2008

38

[IEEE 2009 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC 2009) - Orlando, FL (2009.10.24-2009.11.1)] 2009 IEEE Nuclear Science Symposium Conference Record (NSS/MIC) - The effect of beam polarization in Microbeam Radiation Therapy (MRT): Monte Carlo simulations using Geant4

Spiga, J., Prezado, Y., Brauer-Krisch, E., Fanti, V., Randaccio, P., Bravin, A.

Year:

2009

Language:

english

File:

PDF, 498 KB

english, 2009

39

Influence of polarization and a source model for dose calculation in MRT

Bartzsch, Stefan, Lerch, Michael, Petasecca, Marco, Bräuer-Krisch, Elke, Oelfke, Uwe

Journal:

Medical Physics

Year:

2014

Language:

english

File:

PDF, 2.09 MB

english, 2014

40

Bystander effects in tumor-free and tumor-bearing rat brains following irradiation by synchrotron X-rays

Fernandez-Palomo, Cristian, Schültke, Elisabeth, Smith, Richard, Bräuer-Krisch, Elke, Laissue, Jean, Schroll, Christian, Fazzari, Jennifer, Seymour, Colin, Mothersill, Carmel

Journal:

International Journal of Radiation Biology

Year:

2013

Language:

english

File:

PDF, 607 KB

english, 2013

41

Irradiation of intracerebral 9L gliosarcoma by a single array of microplanar x-ray beams from a synchrotron: balance between curing and sparing

Regnard, Pierrick, Duc, Géraldine Le, Bräuer-Krisch, Elke, Troprès, Irène, Siegbahn, Erik Albert, Kusak, Audrey, Clair, Charlotte, Bernard, Hélène, Dallery, Dominique, Laissue, Jean A, Bravin, Alberto

Journal:

Physics in Medicine and Biology

Year:

2008

Language:

english

File:

PDF, 459 KB

english, 2008

42

[IEEE 2007 IEEE Nuclear Science Symposium Conference Record - Honolulu, HI, USA (2007.10.26-2007.11.3)] 2007 IEEE Nuclear Science Symposium Conference Record - Geant4 simulations for microbeam radiation therapy (MRT) dosimetry

Spiga, J., Siegbahn, E. A., Brauer-Krisch, E., Randaccio, P., Bravin, A.

Year:

2007

Language:

english

File:

PDF, 364 KB

english, 2007

43

Identification of AREG and PLK1 pathway modulation as a potential key of the response of intracranial 9L tumor to microbeam radiation therapy

Bouchet, Audrey, Sakakini, Nathalie, Atifi, Michèle El, Le Clec'h, Céline, Bräuer-Krisch, Elke, Rogalev, Léonid, Laissue, Jean Albert, Rihet, Pascal, Le Duc, Géraldine, Pelletier, Laurent

Journal:

International Journal of Cancer

Year:

2015

Language:

english

File:

PDF, 808 KB

english, 2015

44

Synchrotron X-ray microbeams: A promising tool for drug-resistant epilepsy treatment

Studer, F., Serduc, R., Pouyatos, B., Chabrol, T., Bräuer-Krisch, E., Donzelli, M., Nemoz, C., Laissue, J.A., Estève, F., Depaulis, A.

Journal:

Year:

2015

Language:

english

File:

PDF, 2.23 MB

english, 2015

45

Medical physics aspects of the synchrotron radiation therapies: Microbeam radiation therapy (MRT) and synchrotron stereotactic radiotherapy (SSRT)

Bräuer-Krisch, Elke, Adam, Jean-Francois, Alagoz, Enver, Bartzsch, Stefan, Crosbie, Jeff, DeWagter, Carlos, Dipuglia, Andrew, Donzelli, Mattia, Doran, Simon, Fournier, Pauline, Kalef-Ezra, John, Kock,

Journal:

Year:

2015

Language:

english

File:

PDF, 3.17 MB

english, 2015

46

Micrometer-resolved film dosimetry using a microscope in microbeam radiation therapy

Bartzsch, Stefan, Lott, Johanna, Welsch, Katrin, Bräuer-Krisch, Elke, Oelfke, Uwe

Journal:

Medical Physics

Year:

2015

Language:

english

File:

PDF, 4.02 MB

english, 2015

47

Transmission of Signals from Rats Receiving High Doses of Microbeam Radiation to Cage Mates: An Inter-Mammal Bystander Effect

Mothersill, Carmel, Fernandez-Palomo, Cristian, Fazzari, Jennifer, Smith, Richard, Schültke, Elisabeth, Bräuer-Krisch, Elke, Laissue, Jean, Schroll, Christian, Seymour, Colin

Journal:

Year:

2014

Language:

english

File:

PDF, 1.87 MB

english, 2014

48

Microbeam radiation therapy: Clinical perspectives

Grotzer, M.A., Schültke, E., Bräuer-Krisch, E., Laissue, J.A.

Journal:

Year:

2015

Language:

english

File:

PDF, 223 KB

english, 2015

49

Investigation of UV optical fibers under synchrotron irradiation

Sporea, Dan, Mihai, Laura, Sporea, Adelina, Lixandru, Alin, Bräuer-Krisch, Elke

Journal:

Year:

2014

Language:

english

File:

PDF, 4.21 MB

english, 2014

50

Brain tumor vessel response to synchrotron microbeam radiation therapy: a short-term in vivo study

Serduc, Raphaël, Christen, Thomas, Laissue, Jean, Farion, Régine, Bouchet, Audrey, Sanden, Boudewijn van der, Segebarth, Christoph, Bräuer-Krisch, Elke, Le Duc, Géraldine, Bravin, Alberto, Rémy, Chant

Journal:

Physics in Medicine and Biology

Year:

2008

Language:

english

File:

PDF, 459 KB

english, 2008